New evidence that lactoferrin reduces the prevalence of tummy troubles in toddlers

Lactoferrin is receiving increased interest from researchers for its beneficial effects on the immune system in infants and younger children. Recent Japanese research showed children with an increased dietary lactoferrin intake had a 33% reduction in the prevalence of diarrhea, vomiting and fatigue. The study involved children aged 12 – 32 months old that were given growing up milk with added lactoferrin and then compared to a “control” group that did not receive the added lactoferrin.

This research builds on a significant database of scientific knowledge that supplement manufacturers can utilise to develop nutrition products containing lactoferrin. Consumer demand is increasing for immune products. The proportion of families that have both parents in the workforce is increasing, which also increases the time children spend in pre-school or daycare. This opens opportunities to help parents support the health of their children’s immune system and minimise the impacts of acute gastrointestinal symptoms for kids and parents alike.

Further information on the study results below.

Effects of Lactoferrin-Fortified Formula on Acute Gastrointestinal Symptoms in Children Aged 12–32 Months: A Randomized, Double-Blind, Placebo-Controlled Trial
A randomised, double-blind, placebo controlled study by Motoki et al. in 2020 evaluated the efficacy of lactoferrin from cows milk (bLf) added to growing up milk in preschool aged children. The primary study outcome was the prevalence of respiratory and gastrointestinal symptoms. Japanese children aged 12-32months were enrolled in the study and randomised into two groups, 101 children completed study. The 53 children in the treatment group were provided 48mg of bLf a day, added to a growing up milk. While the 48 children in the control group received only growing up milk. The prevalence of symptoms was reported by parents during the 13 week trial.Those children in the treatment group demonstrated a 33% reduction in the prevalence of acute gastrointestinal symptoms, which include diarrhea, vomiting and fatigue whereas the acute respiratory symptoms were comparable between the groups.

The study highlights the consumption of lactoferrin in growing up milk supports a decrease in the prevalence of acute gastrointestinal symptoms in children 12 – 32months.

Full study: Motoki N, et al. (2020) Effects of Lactoferrin-Fortified Formula on Acute Gastrointestinal Symptoms in ChildrenAged 12–32 Months: A Randomized,Double-Blind, Placebo-Controlled Trial. Front. Pediatr. 8:233. doi: 10.3389/fped.2020.00233

New study shows lactoferrin may help with school gastroenteritis

School gastroenteritis is no laughing matter. It means major disruptions on children, families and teachers. A new large scale study of preschool children in Japan compared kids that were fed yoghurt containing lactoferrin to a control group that wasn’t. The study saw a 49% reduction in absent days from school from gastroenteritis.

This is welcome news for consumers and manufacturers. Lactoferrin’s health properties are increasingly being recognised in a positive prevention role, and in broader age groups. This gives supplement manufacturers new possibilities for product innovation and support for realising new market opportunities.

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Study results summary

The Preventive effect of Lactoferrin-Containing Yogurt on Gastroenteritis in Nursery School Children.

A randomised prospective study by Tsukahara et al. in 2020 evaluated the efficacy of bLf on gastroenteritis in preschool aged children during the winter season. Pre-school children aged 3-6 years were enrolled in the study and randomised into two groups. 1162 children completed the study. The 578 children in the treatment group were provided 100mg of bLf in yogurt once a day, while the 584 children in the control group received a fruit jelly.

Those children consuming 100mg bLf a day, for at least 3 days a week over a 15 week period demonstrated a significantly lower rate of absent days from school due to vomiting.
The study highlights the consumption of 100mg of lactoferrin in yogurt for more than 3 days/week might help alleviate the symptom of vomiting in preschool aged school children during the winter.

Tsukahara Lactoferrin study on gastroenteritis reduction in pre-school children

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